:root {
  --bg: #edf4f7;
  --bg-deep: #dce9ef;
  --panel: rgba(255, 255, 255, 0.9);
  --panel-strong: #ffffff;
  --line: #c7d7e2;
  --line-strong: #a8bfce;
  --ink: #12243f;
  --muted: #577089;
  --accent: #136b74;
  --accent-soft: #d9edf0;
  --chip: #eaf1f7;
  --shadow: 0 18px 48px rgba(36, 70, 104, 0.12);
}

* {
  box-sizing: border-box;
}

body {
  margin: 0;
  min-height: 100vh;
  font-family: "Manrope", sans-serif;
  color: var(--ink);
  background:
    radial-gradient(circle at top left, rgba(19, 107, 116, 0.12), transparent 30%),
    radial-gradient(circle at 85% 20%, rgba(53, 108, 164, 0.12), transparent 28%),
    linear-gradient(180deg, var(--bg), var(--bg-deep));
}

.page-glow {
  position: fixed;
  width: 22rem;
  height: 22rem;
  border-radius: 999px;
  filter: blur(80px);
  opacity: 0.35;
  pointer-events: none;
}

.glow-a {
  top: -6rem;
  left: -4rem;
  background: rgba(19, 107, 116, 0.28);
}

.glow-b {
  right: -4rem;
  top: 8rem;
  background: rgba(87, 112, 137, 0.22);
}

.shell {
  width: min(1280px, 94vw);
  margin: 1.2rem auto 2rem;
  position: relative;
  z-index: 1;
}

.panel {
  background: var(--panel);
  backdrop-filter: blur(10px);
  border: 1px solid rgba(199, 215, 226, 0.8);
  border-radius: 20px;
  box-shadow: var(--shadow);
  padding: 0.9rem 1.05rem;
  margin-bottom: 0.65rem;
}

.hero {
  display: grid;
  grid-template-columns: 1.8fr 1.05fr;
  gap: 0.65rem;
  align-items: center;
}

.eyebrow {
  display: inline-flex;
  padding: 0.28rem 0.58rem;
  border-radius: 999px;
  background: rgba(19, 107, 116, 0.1);
  color: var(--accent);
  font-size: 0.72rem;
  font-weight: 800;
  letter-spacing: 0.04em;
  text-transform: uppercase;
}

h1,
h2 {
  margin: 0;
}

h1 {
  font-size: clamp(1.55rem, 3vw, 2.25rem);
  line-height: 1.02;
  margin-top: 0.35rem;
}

h1 em {
  font-style: italic;
}

h2 {
  font-size: 1.5rem;
}

.hero-copy,
.summary,
.hint {
  color: var(--muted);
}

.hero-copy {
  max-width: 52rem;
  margin-top: 0.35rem;
  line-height: 1.35;
  font-size: 0.95rem;
}

.hero-stats {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: 0.45rem;
}

.stat-card {
  background: linear-gradient(180deg, rgba(255, 255, 255, 0.92), rgba(238, 246, 249, 0.96));
  border: 1px solid var(--line);
  border-radius: 16px;
  padding: 0.58rem 0.72rem;
}

.stat-label {
  display: block;
  color: var(--muted);
  font-size: 0.7rem;
  text-transform: uppercase;
  letter-spacing: 0.04em;
  margin-bottom: 0.2rem;
}

.stat-card strong {
  font-size: 0.98rem;
}

.controls-grid {
  display: grid;
  grid-template-columns: 1.1fr 2fr 0.8fr 1fr 1.15fr;
  gap: 0.7rem;
  align-items: start;
}

.field {
  display: flex;
  flex-direction: column;
  gap: 0.25rem;
}

.field-wide {
  min-width: 0;
}

label {
  font-size: 0.84rem;
  font-weight: 800;
  color: #526b86;
}

input,
select,
button {
  font: inherit;
}

input,
select {
  width: 100%;
  border: 1px solid var(--line);
  background: rgba(255, 255, 255, 0.92);
  color: var(--ink);
  border-radius: 14px;
  padding: 0.64rem 0.8rem;
}

input:focus,
select:focus,
button:focus {
  outline: 2px solid #e39c35;
  outline-offset: 1px;
}

.toggle-group {
  display: flex;
  gap: 0.45rem;
}

.toggle,
.ghost-btn,
.mini-btn {
  border: 1px solid var(--line);
  background: rgba(255, 255, 255, 0.9);
  color: var(--ink);
  border-radius: 16px;
  cursor: pointer;
  transition: 0.16s ease;
}

.toggle {
  flex: 1;
  padding: 0.64rem 0.8rem;
  font-weight: 800;
}

.toggle.active {
  background: linear-gradient(135deg, rgba(19, 107, 116, 0.14), rgba(19, 107, 116, 0.06));
  border-color: #90c7cc;
  color: #0f5a62;
}

.ghost-btn {
  padding: 0.62rem 0.78rem;
  text-align: left;
  font-weight: 800;
  border-style: dashed;
}

.ghost-btn:hover,
.mini-btn:hover,
.toggle:hover {
  transform: translateY(-1px);
  border-color: var(--line-strong);
}

.action-stack {
  display: grid;
  gap: 0.35rem;
}

.section-head {
  display: flex;
  justify-content: space-between;
  align-items: end;
  gap: 1rem;
  margin-bottom: 0.55rem;
}

.section-title {
  display: flex;
  flex-direction: column;
  gap: 0.22rem;
}

.inline-field {
  width: 118px;
}

.chips {
  display: flex;
  flex-wrap: wrap;
  gap: 0.35rem;
  margin-bottom: 0.55rem;
  min-height: 1.5rem;
}

.chip {
  display: inline-flex;
  align-items: center;
  gap: 0.25rem;
  padding: 0.34rem 0.58rem;
  border-radius: 999px;
  background: var(--chip);
  color: #26466a;
  font-weight: 700;
  font-size: 0.88rem;
}

.table-wrap {
  overflow-x: auto;
  border-radius: 18px;
}

table {
  width: 100%;
  border-collapse: collapse;
  min-width: 680px;
}

th,
td {
  padding: 0.52rem 0.5rem;
  border-bottom: 1px solid var(--line);
  vertical-align: middle;
}

th {
  background: #f4f7fb;
  text-align: left;
  color: #233a59;
  font-size: 0.88rem;
  letter-spacing: 0.02em;
}

.empty-state-cell {
  padding: 1rem 0.75rem;
  color: var(--muted);
  font-weight: 700;
}

.ranking-table .rank-col {
  width: 128px;
}

.ranking-table .gene-col {
  width: 240px;
}

.ranking-table .intensity-col {
  width: 260px;
}

.rank-pill {
  display: inline-flex;
  min-width: 4rem;
  justify-content: center;
  padding: 0.28rem 0.58rem;
  border-radius: 999px;
  background: #ecf1f8;
  color: #244b76;
  font-weight: 800;
}

.gene-link-wrap {
  display: inline-flex;
  align-items: center;
  flex-wrap: wrap;
  gap: 0.4rem;
}

.gene-link,
.gene-link:visited {
  color: #163e6d;
  font-weight: 800;
  text-decoration: underline;
  text-decoration-color: rgba(22, 62, 109, 0.3);
}

.mini-link,
.mini-link:visited {
  color: #5a7698;
  font-size: 0.75rem;
  text-decoration: none;
}

.rank-bar {
  position: relative;
  height: 14px;
  border-radius: 999px;
  background: linear-gradient(90deg, rgba(207, 216, 227, 0.72), rgba(19, 107, 116, 0.8));
  overflow: visible;
}

.rank-bar::after {
  content: "";
  position: absolute;
  inset: 0;
  border-radius: 999px;
  box-shadow: inset 0 0 0 1px rgba(255, 255, 255, 0.35);
}

.rank-marker {
  position: absolute;
  top: 50%;
  width: 16px;
  height: 16px;
  transform: translate(-50%, -50%);
  border-radius: 999px;
  background: #0f6a73;
  border: 3px solid rgba(255, 255, 255, 0.92);
  box-shadow: 0 2px 10px rgba(18, 36, 63, 0.22);
}

.intensity-head {
  display: flex;
  flex-direction: column;
  gap: 0.22rem;
}

.rank-scale {
  position: relative;
  height: 16px;
}

.rank-scale::before {
  content: "";
  position: absolute;
  left: 0;
  right: 0;
  top: 3px;
  border-top: 2px dashed rgba(19, 107, 116, 0.42);
}

.rank-scale-tick {
  position: absolute;
  top: 0;
  transform: translateX(-50%);
  color: #337b85;
  font-weight: 800;
  font-size: 0.72rem;
}

.rank-scale-tick-line {
  display: block;
  width: 2px;
  height: 8px;
  margin: 0 auto 0.08rem;
  background: rgba(51, 123, 133, 0.65);
}

.profile-controls {
  margin-bottom: 0.55rem;
}

.profile-toolbar {
  display: flex;
  gap: 1rem;
  align-items: start;
  flex-wrap: wrap;
}

.profile-condition-box {
  width: fit-content;
  max-width: 100%;
}

.profile-pattern-box {
  min-width: 220px;
  max-width: 280px;
}

.profile-pattern-box select {
  margin-bottom: 0.3rem;
}

.mini-actions {
  display: flex;
  gap: 0.45rem;
  margin: 0.2rem 0 0.35rem;
}

.mini-btn {
  padding: 0.34rem 0.65rem;
  border-radius: 999px;
  font-size: 0.82rem;
  font-weight: 700;
}

#profileConditionSelect {
  width: 16rem;
  min-width: 16rem;
  max-width: 16rem;
  height: 11rem;
}

.profile-gene-cell {
  font-weight: 800;
}

.profile-rank {
  display: inline-flex;
  min-width: 3.5rem;
  justify-content: center;
  padding: 0.26rem 0.46rem;
  border-radius: 999px;
  font-weight: 800;
}

.analysis-grid {
  display: grid;
  grid-template-columns: 1fr;
  gap: 0.75rem;
}

.summary-accordion-wrap {
  width: 100%;
}

.summary-accordion {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 0.5rem;
  align-items: start;
}

.summary-item {
  border: 1px solid var(--line);
  border-radius: 16px;
  background: rgba(255, 255, 255, 0.7);
  overflow: hidden;
  align-self: start;
}

.summary-item[open] {
  background: rgba(255, 255, 255, 0.92);
  border-color: var(--line-strong);
  grid-column: 1 / -1;
}

.summary-item-head {
  list-style: none;
  cursor: pointer;
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 1rem;
  padding: 0.62rem 0.78rem;
  font-weight: 800;
  color: #213a58;
}

.summary-item-head::-webkit-details-marker {
  display: none;
}

.summary-condition {
  flex: 0 0 150px;
}

.summary-preview {
  flex: 1;
  color: var(--muted);
  font-weight: 700;
  font-size: 0.82rem;
}

.summary-item-body {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: 0.8rem;
  padding: 0 0.78rem 0.72rem;
  border-top: 1px solid rgba(199, 215, 226, 0.7);
}

.summary-gene-block h3 {
  margin: 0.55rem 0 0.35rem;
  font-size: 0.82rem;
  color: #526b86;
}

.gene-rank-list {
  margin: 0;
  padding-left: 1.2rem;
  line-height: 1.18;
  font-size: 0.9rem;
}

.gene-rank-list li {
  margin: 0 0 0.12rem;
}

.gene-rank-list li:last-child {
  margin-bottom: 0;
}

@media (max-width: 920px) {
  .shell {
    width: 95vw;
  }

  .hero,
  .analysis-grid,
  .controls-grid {
    grid-template-columns: 1fr;
  }

  .hero-stats,
  .summary-accordion {
    grid-template-columns: 1fr;
  }

  .profile-toolbar {
    flex-direction: column;
    gap: 0.5rem;
  }

  .inline-field {
    width: 100px;
  }

  .summary-item-body {
    grid-template-columns: 1fr;
    gap: 0.4rem;
  }

  .summary-item-head {
    flex-direction: column;
    align-items: start;
  }

  .summary-condition {
    flex: none;
  }
}